| Head south on Вука Пантелића | 100 m |
| Turn left onto Драгољуба Миленковића | 200 m |
| Turn right onto Српских владара | 900 m |
| Enter the traffic circle and take the 4th exit onto Српских владара | 25 m |
| Exit the traffic circle onto Српских владара | 2.5 km |
| Go straight onto 259 | 800 m |
| Take the ramp on the right | 300 m |
| Keep left at the fork | 600 m |
| Merge left towards A 4: Sofia (BG) | 25 km |
| Continue onto Автомагистрала Европа (A 6) | 35 km |
| Keep left towards 8 | 15 km |
| Enter the traffic circle and take the 1st exit towards Перник | 8 m |
| Exit the traffic circle towards Перник | 400 m |
| Take the ramp on the left | 90 m |
| Merge left onto Околовръстен път (18) | 2 km |
| Keep left onto Автомагистрала Струма (A 3) | 100 km |
| Continue onto 1 | 25 km |
| Enter the traffic circle and take the 1st exit towards А 3: Сандански | 45 m |
| Exit the traffic circle towards А 3: Сандански | 500 m |
| Continue slightly right onto Автомагистрала Струма (A 3) | 40 km |
| Keep left onto Автомагистрала Струма (A 3) | 450 m |
| Continue onto Τελωνείο Προμαχώνα (ΕΟ63) | 600 m |
| Continue onto Θεσσαλονίκη - Προμαχώνας (ΕΟ63) | 30 km |
| Take exit 9 towards Σέρρες | 1 km |
| Continue towards Σέρρες | 500 m |
| Keep left towards Σέρρες | 3 km |
| Turn left onto Θεσσαλονίκης - Σερρών (ΕΟ12) | 60 m |
| Make a slight right | 40 m |
| Go straight onto Περιφερειακή Οδός Σερρών | 10 km |
| Turn right onto Σερρών - Δράμας (ΕΟ12) | 25 km |
| Turn right onto Αμφίπολης - Σερρών (ΕΟ59) | 20 km |
| Turn right to stay on Αμφίπολης - Σερρών (ΕΟ59) | 8 km |
| Turn left onto Συνδετήρια Οδός | 250 m |
| Take the ramp on the right towards Θεσσαλονίκη | 200 m |
| Merge left onto Εγνατία Οδός (Α2) | 20 km |
| Take the ramp towards Ασπροβάλτα | 700 m |
| Continue towards Ασπροβάλτα | 800 m |
| Turn left towards Ασπροβάλτα | 30 m |
| Continue onto Θεσσαλονίκης - Καβάλας (ΕΟ2) | 2 km |
| Turn right onto Παύλου Μελά | 30 m |
| You have arrived at your destination, on the left | 0 m |