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Agrinio – Makedonski Brod
Ιόνια Οδός, Εγνατία Οδός
461.4 km, 6 h 16 min
| Head northwest on Βότση | 200 m | |
| Turn right onto Τσικνιά | 250 m | |
| Continue onto Σκαλτσοδήμου | 250 m | |
| Make a slight left to stay on Βλαχοπούλου | 100 m | |
| Turn right to stay on Βλαχοπούλου | 90 m | |
| Turn left onto Προυσιωτίσσης | 400 m | |
| Continue onto Βενιζέλου Ελευθερίου | 300 m | |
| Continue onto Αγίου Κωνσταντίνου | 1.5 km | |
| Continue onto Αγρίνιο - Γέφυρα Ματσουκίου | 2 km | |
| Turn left | 90 m | |
| Make a slight right | 60 m | |
| Go straight onto Αντιρρίου - Ιωαννίνων (ΕΟ5) | 15 km | |
| Make a slight right towards A5: Ιωάννινα | 35 m | |
| Take the ramp towards A5: Ιωάννινα | 350 m | |
| Merge left onto Ιόνια Οδός (Α5) | 100 km | |
| Take the ramp towards Επισκοπικό | 800 m | |
| Enter the traffic circle and take the 3rd exit onto Αντίρριο - Ιωάννινα (ΕΟ5) | 100 m | |
| Exit the traffic circle onto Αντίρριο - Ιωάννινα (ΕΟ5) | 6 km | |
| Turn right onto Αντίρριο - Ιωάννινα (ΕΟ5) | 20 m | |
| Turn left to stay on Αντίρριο - Ιωάννινα (ΕΟ5) | 700 m | |
| Take the ramp towards Α2: Γρεβενά | 400 m | |
| Merge left onto Εγνατία Οδός (Α2) | 50 km | |
| Take the ramp | 100 m | |
| Continue straight | 150 m | |
| Merge left onto Εγνατία Οδός (Α2) | 90 km | |
| Take the ramp towards Α27: Σκόπια | 550 m | |
| Merge left onto Κοζάνη - Πτολεμαΐδα - Νίκη (Α27) | 800 m | |
| Continue towards Ptolemaida | 800 m | |
| Continue towards Ptolemaida | 40 km | |
| Merge left onto Φλώρινας - Θεσσαλονίκης | 15 km | |
| Turn left onto Αμύνταιου - Φλώρινας (ΕΟ3) | 3 km | |
| Turn left onto Κοζάνη - Πτολεμαΐδα - Νίκη | 25 km | |
| Turn right onto ΕΟ3 | 700 m | |
| Continue onto A3.1 | 15 km | |
| Turn right onto Никола Тесла (A3.1) | 550 m | |
| Turn right onto 4. Ноември (A3.1) | 250 m | |
| Turn right onto Македонски Гемиџии (A3.1) | 3 km | |
| Continue onto Владимир Назор (A3.1) | 2.5 km | |
| Keep left onto A3.1 | 20 km | |
| Enter the traffic circle and take the 1st exit onto R1101 | 55 m | |
| Exit the traffic circle onto R1101 | 6 km | |
| Make a slight right | 80 m | |
| Continue onto A3 | 6 km | |
| Continue onto A1.1 | 3.5 km | |
| Take the ramp | 500 m | |
| Continue onto Цар Самоил | 1.5 km | |
| Continue onto Сотир Ѓорѓиоски-Сотка | 300 m | |
| Continue onto Народен Херој Кузман Јосифоски-Питу | 200 m | |
| Enter the traffic circle and take the 1st exit onto Ѓорѓи Делчев-Гоце (R1312) | 6 m | |
| Exit the traffic circle onto Ѓорѓи Делчев-Гоце (R1312) | 300 m | |
| Turn left onto Прилепски Бранители | 200 m | |
| Enter the traffic circle and take the 2nd exit onto Прилепски Бранители | 25 m | |
| Exit the traffic circle onto Прилепски Бранители | 1 km | |
| Continue onto Народен Херој Јордан Чопела-Кулак | 3.5 km | |
| Continue onto R1303 | 30 km | |
| Turn left onto R1303 | 1.5 km | |
| Turn right onto Алкалоид | 1.5 km | |
| Turn left onto Крушевска Република | 35 m | |
| Turn right onto Кирил и Методиј | 200 m | |
| Turn left onto Првомајска | 300 m | |
| Turn left onto Илија Игески-Цветан | 5.5 m | |
| You have arrived at your destination, on the left | 0 m |
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