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Regina – Lexington
I 94, I 65
2452.5 km, 29 h
| Head north on Albert Street | 30 m | |
| Make a U-turn and continue on Albert Street | 6 km | |
| Continue onto CanAm Highway (6) | 100 km | |
| Continue onto Highway 39 (39) | 80 km | |
| Turn left onto Highway 39 (39) | 15 km | |
| Turn left to stay on Highway 39 (39) | 35 km | |
| Keep left at the fork | 20 m | |
| Take the ramp | 150 m | |
| Merge left onto US 52 | 10 km | |
| Turn left onto United States Highway 52 (US 52) | 45 km | |
| Continue onto 506th Street Northwest (US 52) | 35 km | |
| Continue onto 2nd Avenue (US 52) | 60 km | |
| Take the ramp towards US 52 East: Jamestown | 600 m | |
| Turn right onto US 52 | 100 km | |
| Continue onto United State Highway 52 (US 52) | 450 m | |
| Continue onto 23rd Street Northeast (US 52) | 45 km | |
| Turn left onto United States Highway 52 (US 52) | 35 km | |
| Turn right onto 19th Avenue (1605) | 1.5 km | |
| Turn left onto 7th Street South | 1.5 km | |
| Turn right onto 4th Avenue South (US 52) | 60 km | |
| Turn right onto US 52 Bypass (US 52 Truck) | 4.5 km | |
| Continue onto 81st Street Southeast (US 52 Truck) | 1.5 km | |
| Take the ramp on the left towards Fargo | 15 km | |
| Continue onto I 94 | 300 km | |
| Continue onto I 94 | 200 km | |
| Keep left onto I 694 | 10 km | |
| Keep right towards MN 51: Snelling Ave | 450 m | |
| Merge left onto US 10 | 7 km | |
| Keep right towards US 10 East: St Paul | 9 km | |
| Keep left towards US 10 East: 10th Street | 900 m | |
| Keep left onto I 94 | 3 km | |
| Keep left onto I 94 | 400 km | |
| Keep right towards I 39: Chicago | 100 km | |
| Keep left onto Jane Addams Memorial Tollway (I 90) | 35 km | |
| Keep right onto Jane Addams Memorial Tollway (I 90) | 70 km | |
| Keep left onto Jane Addams Memorial Tollway (I 90) | 2 km | |
| Merge right onto Kennedy Expressway (I 90) | 15 km | |
| Keep right onto Kennedy Expressway (I 90) | 9 km | |
| Continue onto Dan Ryan Expressway (I 90) | 4 km | |
| Keep left towards I 90 Express | 6 km | |
| Take exit 59A towards I 90 East | 700 m | |
| Merge right onto Dan Ryan Expressway (Local) (I 90) | 800 m | |
| Keep left towards I 90 East | 7 km | |
| Take the ramp on the left | 200 m | |
| Merge right onto Chicago Skyway (I 90) | 5 km | |
| Continue onto Indiana Toll Road (I 90) | 4.5 km | |
| Keep left onto Indiana Toll Road (I 90) | 20 km | |
| Take exit 14B towards SR 53: Broadway | 450 m | |
| Turn right onto Broadway (SR 53) | 300 m | |
| Turn left onto East 5th Avenue (US 12) | 2.5 km | |
| Turn right onto I 65 | 200 km | |
| Keep left onto I 65 | 25 km | |
| Continue towards I 70 East: Dayton | 3 km | |
| Keep left onto I 65 | 150 km | |
| Take exit 6A towards SR 62 East: Jeffersonville | 400 m | |
| Merge left onto SR 265 | 10 km | |
| Continue onto Gene Snyder Freeway (KY 841) | 20 km | |
| Take exit 25A towards I 64 East: Shelbyville | 400 m | |
| Merge left onto I 64 | 60 km | |
| Take exit 58 towards US 60: Frankfort | 500 m | |
| Keep right towards Versailles | 80 m | |
| Merge left onto Versailles Road (US 60) | 1 km | |
| Continue onto Frankfort Highway (US 60) | 3 km | |
| Continue onto Frankfort Road (US 60) | 10 km | |
| Continue onto Versailles Bypass (US 60) | 2.5 km | |
| Make a slight left onto Lexington Road (US 60) | 6 km | |
| Continue onto Versailles Road (US 60) | 7 km | |
| Take the ramp towards KY 4 South: New Circle Road | 600 m | |
| Merge left onto New Circle Road (KY 4) | 9 km | |
| Take exit 18 towards KY 1974: Lexington | 350 m | |
| Turn right onto Tates Creek Road (KY 1974) | 300 m | |
| Turn left onto Gainesway Drive | 1.5 km | |
| Turn left onto Coldstream Drive | 80 m | |
| You have arrived at your destination, on the left | 0 m |
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